Understanding red blood cell alloimmunization triggers
نویسندگان
چکیده
منابع مشابه
Responder individuality in red blood cell alloimmunization.
Many different factors influence the propensity of transfusion recipients and pregnant women to form red blood cell alloantibodies (RBCA). RBCA may cause hemolytic transfusion reactions, hemolytic disease of the fetus and newborn and may be a complication in transplantation medicine. Antigenic differences between responder and foreign erythrocytes may lead to such an immune answer, in part with...
متن کاملRed-blood-cell alloimmunization and number of red-blood-cell transfusions.
BACKGROUND Patients receiving red-blood-cells may form antibodies against the alloantigens expressed by red-blood-cells, with the risk of serious morbidity and the need for extensive phenotype-matching in subsequent transfusions. The incidence of alloimmunization is considered variable for specific patient groups and for first time antibody formation. We therefore studied the cumulative inciden...
متن کاملAllogeneic Red Blood Cell Transfusion Following the Total Hip Arthroplasty Triggers the Immunomodulatory Responses
Background and Aims: Total hip arthroplasty (THA) is a common orthopedic surgery. The main focus in the research of THA is immune responses in these patients following the blood transfusion.Therefore, in this study, we evaluated the immune modulation indexes such as T cell amplification, Tcell surface markers and also production of cytokines in the patients undergoing THA surgery following bloo...
متن کاملRed Blood Cell Alloimmunization in Patients with Thalassemia Major and Intermediate in Southwest Iran
Background: Transfusion is the mainstay treatment of patients with thalassemia major and occasionally in thalassemia intermediate. Alloimmunization is an unwanted side effect of blood transfusion. The present study intended to determine the frequency of alloimmunization in patients with β- thalassemia major and thalassemia intermediate in Southwest Iran. Patients and Methods: This was a cross-...
متن کاملRed blood cell antigen alloimmunization: Mysteries still unsolved
Article history: Received 10 June 2016 Accepted 10 June 2016 Available online 16 June 2016 pletion studies. They confirm the profound effect of storage on alloimmunization in this clear-cut model but also observe that NLRP3/ caspase-1 is not required for the effect (Gibb et al., 2016). While these data reject a relevant hypothesis that NLRP/caspase-1 is required (e.g. negative data), they do no...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hematology
سال: 2016
ISSN: 1520-4391,1520-4383
DOI: 10.1182/asheducation-2016.1.446